Disease proteomics

[Proteomics and cardiovascular disease].

The description of the human genome has opened new venues for the study and understanding of pathophysiological phenomena. In the 20th century, individual cell components were studied. The 21st century began with a global analysis of cell components. Thanks to the development of new technologies such as DNA chips, or two-dimensional electrophoresis, we can now study the expression of thousands ...

Proteomics of Alzheimer’s Disease

Proteomics-Based Disease Biomarkers

Sequencing of the human genome has greatly impacted the proteomics-based analysis of disease by providing a framework for understanding the proteome of diseased cells, tissues, and biological fluids. Consequently, there is a growing interest in applying proteomics technologies to define protein pathways involved in various diseases, to identify new biomarkers that correlate with diseases, ideal...

Proteomics Discovery of Disease Biomarkers

Recent technological developments in proteomics have shown promising initiatives in identifying novel biomarkers of various diseases. Such technologies are capable of investigating multiple samples and generating large amount of data end-points. Examples of two promising proteomics technologies are mass spectrometry, including an instrument based on surface enhanced laser desorption/ionization,...

Proteomics in Health and Disease

One of the major goals of the postgenomic era is understanding the structures, interactions, and functions of all cell proteins. This becomes a daunting task considering the estimation that there are between 100 000 and 200 000 individual proteins resulting from alternative splicing of the 30 000 genes encoded by the human genome. Since the cellular proteome is a dynamic profile, subject to cha...